There is relatively little numerical study on the behavior of eccentrically loaded high strength rectangular concrete-filled steel tubular (CFST) slender beam-columns with large depth-to-thickness ratios, which may undergo local and global buckling. This paper presents a multi scale numerical model for simulating the interaction local and global buckling behavior of hlgh strength thin-walled rectangular CFST slender beam-columns under eccentric loading. The effects of progressive local buckling are taken into account in the mesoscale model based on fiber element formulations. Computational algorithms based on the Muller's method are developed to obtain complete load-deflection responses of CFST slender beam-columns at the macroscale level. Performance indices are proposed to quantify the performance of CFST slender beam-columns. The accuracy of the multiscale numerical model is examined by comparisons of computer solutions with existing experimental results. The numerical model is utilized to investigate the effects of concrete compressive strength, depth-to-thickness ratio, loading eccentricity ratio and column slenderness ratio on the performance indices. The multiscale numerical model is shown to be accurate and efficient for predicting the interaction buckling behavior of high strength thin-walled CFST slender beam-columns.