Title

Evaluating the stability of three oxidative stress biomarkers undersewer conditions and potential impact for use in wastewater-based epidemiology

RIS ID

139102

Publication Details

O'Brien, J. W., Choi, P. M., Li, J., Thai, P. K., Jiang, G., Tscharke, B. J., Mueller, J. F. & Thomas, K. V. (2019). Evaluating the stability of three oxidative stress biomarkers undersewer conditions and potential impact for use in wastewater-based epidemiology. Water Research, 166 115068-1-115068-7.

Abstract

Wastewater contains a wealth of information about the population who contribute to it including biological and chemical markers of human activity and exposures. F2-isoprostanes have been proposed as oxidative stress biomarkers that can be measured in wastewater to provide a measure of oxidative stress at the population level. While an association between tobacco use and their level in wastewater has been demonstrated, an in-sewer stability assessment has not been conducted to support their use as oxidative stress biomarkers for wastewater-based epidemiology studies. In this study we investigated the stability of 8-iso-prostaglandin F2α (PGF2α), its metabolite dinor-11β-Prostaglandin F2α (dnPGF2α) and Prostaglandin E2 (PGE2) (representative of other classes of prostaglandins) in laboratory-scale sewer reactors simulating real sewers. PGF2α, dnPGF2α and PGE2 were all found to be sufficiently stable under typical sewer conditions therefore satisfying the stability requirement of wastewater-based epidemiology population health biomarkers.

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Link to publisher version (DOI)

http://dx.doi.org/10.1016/j.watres.2019.115068