Publication Details

Buckley, J. G., Rai, R., Liney, G. P., Dowling, J. A., Holloway, L. C., Metcalfe, P. E. & Keall, P. J. (2019). Anatomical deformation due to horizontal rotation: towards gantry-free radiation therapy. Physics in Medicine and Biology, 64 (17), 175014-1-175014-12.


Gantry-free radiation therapy systems may be simpler and more cost effective, particularly for MRI-guided photon or hadron therapy. This study aims to understand and quantify anatomical deformations caused by horizontal rotation with scan sequences sufficiently short to facilitate integration into an MRI-guided workflow. Rigid and non-rigid pelvic deformations due to horizontal rotation were quantified for a cohort of 8 healthy volunteers using a bespoke patient rotation system and a clinical MRI scanner. For each volunteer a reference scan was acquired at 0° followed by sequential faster scans in 45° increments through to 360°. All fast scans were registered to the 0° image via a three-step process: first, images were aligned using MR visible couch markers. Second, the scans were pre-processed then rigidly registered to the 0° image. Third, the rigidly registered scans were non-rigidly registered to the 0° image to assess soft tissue deformation. The residual differences after rigid and non-rigid registration were determined from the transformation matrix and the deformation vector field, respectively. The rigid registration yielded mean rotations of  ⩽2.5° in all cases. The average 3D translational magnitudes range was 5.8  ±  2.9 mm-30.0  ±  11.0 mm. Translations were most significant in the left-right (LR) direction. Smaller translations were observed in the anterior-posterior (AP) and superior-inferior (SI) directions. The maximum deformation magnitudes range was: 10.0  ±  0.9 mm-28.0  ±  2.8 mm and average deformation magnitudes range: 2.3  ±  0.6 mm-7.5  ±  1.0 mm. Average non-rigid deformation magnitude was correlated with BMI (correlation coefficient 0.84, p   =  0.01). Rigid pelvic deformations were most significant in the LR direction but could be accounted for with on-line adjustments. Non-rigid deformations can be significant and will need to be accounted for in order to facilitate the delivery of gantry-free therapy with an automated patient rotation system.



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