Title

Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA

RIS ID

135852

Publication Details

Sakata, D., Lampe, N., Karamitros, M., Kyriakou, I., Belov, O., Bernal, M. A., Bolst, D., Bordage, M., Breton, V., Brown, J. M. C., Francis, Z., Ivanchenko, V., Meylan, S., Murakami, K., Okada, S., Petrovic, I., Ristic-Fira, A., Santin, G., Sarramia, D., Sasaki, T., Shin, W., Tang, N., Tran, H. N., Villagrasa, C., Emfietzoglou, D., Nieminen, P., Guatelli, S. & Incerti, S. (2019). Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA. Physica Medica: an international journal devoted to the applications of physics to medicine and biology, 62 152-157.

Abstract

The advancement of multidisciplinary research fields dealing with ionising radiation induced biological damage - radiobiology, radiation physics, radiation protection and, in particular, medical physics - requires a clear mechanistic understanding of how cellular damage is induced by ionising radiation. Monte Carlo (MC) simulations provide a promising approach for the mechanistic simulation of radiation transport and radiation chemistry, towards the in silico simulation of early biological damage. We have recently developed a fully integrated MC simulation that calculates early single strand breaks (SSBs) and double strand breaks (DSBs) in a fractal chromatin based human cell nucleus model. The results of this simulation are almost equivalent to past MC simulations when considering direct/indirect strand break fraction, DSB yields and fragment distribution. The simulation results agree with experimental data on DSB yields within 13.6% on average and fragment distributions agree within an average of 34.8%.

Grant Number

ARC/DP170100967

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