In-field and out-of-file application in¹²C ion therapy using fully 3D silicon microdosimeters

Authors

Linh T. Tran, University of WollongongFollow
Lachlan Chartier, University of WollongongFollow
David Bolst, University of WollongongFollow
Jeremy A. Davis, University of WollongongFollow
Dale A. Prokopovich, University of WollongongFollow
Alex Pogossov, University of Wollongong
Susanna Guatelli, University of WollongongFollow
Mark I. Reinhard, University of Wollongong
Marco Petasecca, University of WollongongFollow
Michael L. F Lerch, University of WollongongFollow
Naruhiro Matsufuji, National Institute Of Radiological SciencesFollow
Marco Povoli, University of Oslo
Anand Summanwar, SINTEF
Angela Kok, SINTEFFollow
Michael A. Jackson, University of New South WalesFollow
Anatoly B. Rosenfeld, University of WollongongFollow

RIS ID

128605

Publication Details

Tran, L. T., Chartier, L., Bolst, D., Davis, J., Prokopovich, D. A., Pogossov, A., Guatelli, S., Reinhard, M. I., Petasecca, M., Lerch, M. L. F., Matsufuji, N., Povoli, M., Summanwar, A., Kok, A., Jackson, M. & Rosenfeld, A. B. (2018). In-field and out-of-file application in¹²C ion therapy using fully 3D silicon microdosimeters. Radiation Measurements, 115 55-59.

Abstract

This paper presents recent development of Silicon on Insulator (SOI) detectors for microdosimetry at the Centre for Medical Radiation Physics (CMRP) at the University of Wollongong. A new CMRP SOI microdosimeter design, the 3D mushroom microdosimeter is presented. Modification of SOI design and changes to the fabrication processes have led to improved definition of the microscopic sensitive volumes (SV), and thus to better modelling of the deposition of ionizing energy in a biological cell. The electrical and charge collection properties of the devices have been presented in previous works. In this study, the response of the microdosimeters in monoenergetic and spread out Bragg peak therapeutic ¹²C ion beam at Heavy Ion Medical Accelerator in Chiba (HIMAC, Japan) are presented. Derived relative biological effectiveness (RBE) in ¹²C ion radiation therapy matches the tissue equivalent proportional counter (TEPC) well, along with outstanding spatial resolution. The use of SOI technology in experimental microdosimetry offers simplicity (no gas system or HV supply), high spatial resolution, low cost, high count rates capabilities for beam characterisation and quality assurance (QA) in charged particle therapy.