Geant4 Monte Carlo simulation of absorbed dose and radiolysis yields enhancement from a gold nanoparticle under MeV proton irradiation
Authors
H Tran, Ton Duc Thang University
M Karamitros, University Of Notre Dame
V N. Ivanchenko, Geant4 Associates International Ltd
Susanna Guatelli, University of WollongongFollow
Sally McKinnon, University of WollongongFollow
K Murakami, KEK Tsukuba Ibaraki, Ken, Japan
Takashi Sasaki, KEK Tsukuba Ibaraki, Ken, JapanFollow
Susumu Okada, KEK Tsukuba Ibaraki, Ken, Japan
M Bordage, University Of Toulouse, Inserm, France
Z Francis, Universite Saint Joseph
Z El Bitar, Institut Pluridisciplinaire Hubert Curien
M A. Bernal, Universidade Estadual de Campinas
James Shin, Korea Institute of Radiological And Medical Science, Monash Institute of Pharmaceutical Sciences
Sang Bae Lee, National Cancer Center
P Barberet, CNRS, IN2P3 Gradignan, Universite De Bordeaux
T T. Tran, VNUHCM-University of Science
Jeremy M. C Brown, Queen's University Belfast
T V. Nhan Hao, Duy Tan University, Texas A & M University
Sebastian Incerti, Universite De Bordeaux, Ton Duc Thang University, CNRS, IN2P3 GradignanFollow
Abstract
Gold nanoparticles have been reported as a possible radio-sensitizer agent in radiation therapy due to their ability to increase energy deposition and subsequent direct damage to cells and DNA within their local vicinity. Moreover, this increase in energy deposition also results in an increase of the radiochemical yields. In this work we present, for the first time, an in silico investigation, based on the general purpose Monte Carlo simulation toolkit Geant4, into energy deposition and radical species production around a spherical gold nanoparticle 50 nm in diameter via proton irradiation. Simulations were preformed for incident proton energies ranging from 2 to 170 MeV, which are of interest for clinical proton therapy.
Publication Details
Tran, H. N., Karamitros, M., Ivanchenko, V. N., Guatelli, S., McKinnon, S., Murakami, K., Sasaki, T., Okada, S., Bordage, M. C., Francis, Z., El Bitar, Z., Bernal, M. A., Shin, J. I., Lee, S., Barberet, P., Tran, T. T., Brown, J. M. C., Nhan Hao, T. V. & Incerti, S. (2016). Geant4 Monte Carlo simulation of absorbed dose and radiolysis yields enhancement from a gold nanoparticle under MeV proton irradiation. Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, 373 126-139.