Effect of poling state and morphology of piezoelectric poly(vinylidene fluoride) membranes for skeletal muscle tissue engineering

Authors

P M. Martins, University of Minho
S Ribeiro, University of Minho
Clarisse Ribeiro, University of Minho
Vitor Sencadas, University of WollongongFollow
A C. Gomes, University of Minho
F M. Gama, University of Minho
Senentxu Lanceros-Méndez, University of Minho

RIS ID

99122

Publication Details

Martins, P. M., Ribeiro, S., Ribeiro, C., Sencadas, V., Gomes, A. C., Gama, F. M. & Lanceros-Méndez, S. (2013). Effect of poling state and morphology of piezoelectric poly(vinylidene fluoride) membranes for skeletal muscle tissue engineering. RSC Advances, 3 (39), 17938-17944.

Abstract

This work reports on the influence of polarization and morphology of electroactive poly(vinylidene fluoride), PVDF, on the adhesion and morphology of myoblast cells. Non-poled, "poled+" and "poled-" β-PVDF films were prepared by solvent casting followed by corona poling. Furthermore, random and aligned electrospun β-PVDF fiber mats were also prepared. It is demonstrated that negatively charged surfaces improve cell adhesion and proliferation and that the directional growth of the myoblast cells can be achieved by culturing the cell on aligned fibers. Therefore, the potential application of electroactive materials for muscle regeneration is demonstrated.