Long-term results of Phase II study of high dose photon/proton radiotherapy in the management of spine chordomas, chondrosarcomas, and other sarcomas

Authors

Thomas F. Delaney, Harvard Medical School, Boston
Norbert J. Liebsch, Harvard Medical School, Boston
Frank X. Pedlow, Harvard Medical School, Boston
Judith Adams, Harvard Medical School, Boston
Elizabeth A. Weyman, Harvard Medical School, Boston
Beow Y. Yeap, Harvard Medical School, Boston
Nicolas Depauw, University of WollongongFollow
G. Petur Nielsen, Harvard Medical School, Boston
David C. Harmon, Harvard Medical School, Boston
Sam S. Yoon, Harvard Medical School, Boston
Yen-Lin Chen, Harvard Medical School, Boston
Joseph H. Schwab, Harvard Medical School, Boston
Francis J. Hornicek, Harvard Medical School, Boston

RIS ID

89492

Publication Details

Delaney, T. F., Liebsch, N. J., Pedlow, F. X., Adams, J., Weyman, E. A., Yeap, B. Y., Depauw, N., Nielsen, G. Petur., Harmon, D. C., Yoon, S. S., Chen, Y., Schwab, J. H. & Hornicek, F. J. (2014). Long-term results of Phase II study of high dose photon/proton radiotherapy in the management of spine chordomas, chondrosarcomas, and other sarcomas. Journal of Surgical Oncology, 110 (2), 115-122.

Abstract

Negative surgical margins are uncommon for spine sarcomas; hence, adjuvant radiotherapy (RT) may be recommended but tumor dose may be constrained by spinal cord, nerve and viscera tolernce.

Prospective Phase II clinical trial incorporating high dose RT. Eligible patients had primary or locally recorrent thoracic, lumbar, and/or sacral spine-paraspinal chordomas or sarcomas. Treatment included pre-and/or post-operative photon/proton RT += radical resection.