What approach to brain partial volume correction is best for PET/MRI?



Publication Details

Hutton, B. F., Thomas, B. A., Erlandsson, K., Bousse, A., Reilhac-Laborde, A., Kazantsev, D., Pedemonte, S., Vunckx, K., Arridge, S. & Ourselin, S. (2013). What approach to brain partial volume correction is best for PET/MRI?. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment, 702 29-33.


Many partial volume correction approaches make use of anatomical information, readily available in PET/MRI systems but it is not clear what approach is best. Seven novel approaches to partial volume correction were evaluated, including several post-reconstruction methods and several reconstruction methods that incorporate anatomical information. These were compared with an MRI-independent approach (reblurred van Cittert ) and uncorrected data. Monte Carlo PET data were generated for activity distributions representing both 18F FDG and amyloid tracer uptake. Post-reconstruction methods provided the best recovery with ideal segmentation but were particularly sensitive to mis-registration. Alternative approaches performed better in maintaining lesion contrast (unseen in MRI) with good noise control. These were also relatively insensitive to mis-registration errors. The choice of method will depend on the specific application and reliability of segmentation and registration algorithms.

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