Background: Model of reference family medicine clinic reveals changes in treating patients on primary health level. The consequence is reduction or elimination of risk factors for the occurrence of cardiovascular diseases. Team consists of a doctor, a nurse and a graduate nurse, who significantly improves the quality of controling patients with risk factors by knowledge, proficiency and individual approach. The purpose of master's degree: The purpose of the master's degree thesis is to explore the risk factors for the occurrence of cardiovascular diseases among groups of patients, who are treated in the reference medicine family clinic and general clinic. Research methodology: There was a cross-sectional method of data gathering used in this study. Primary data were collected from the prescribed forms, that are filled in when testing for cardiovascular risk, and are statistically analysed by SPSS program. The following statistical methods were used to examine the data: regression analysis, ANOVA, hi-square and t-test. The theoretical part consists of analysing the literature. The literature has been reviewed on the basis of scientific and technical literature. Results: When doing control measurements patients had settled blood pressure in 41,6 %, settled cholesterol in 45,5 % and settled blood sugar in 53,3 %. All three measurements were higher than in screening tests. There were 23,7 % smokers, which is less than in screening tests. High cardiovascular risk (20 to 40 %) has reduced to a 28,0 %, whereas extremely high cardiovascular risk to a 6,6 %. Physical activity 2-4 times per week was stated in 54,3 %, physical activity 5 times per week was stated in 19,4 %, which is higher than in screening test. The results of the control measurements show statistically significant improvements in following factors (x^2=8,780; p=o,oo3) and cholesterol (x^2=4,781; p=0,029) in patients, studied in the family medicine clinic, whereas blood sugar was no longer statistically significant. When controlling physical activity the result was opposite - subjects treated in reference family medicine clinic stated statistically significant difference (x^2=15,304; p=0,002). Gender comparison in the family medicine clinic once again showed (x^2=19,243; p<0,001). When studying women, the high cardiovascular risk reduced to a 18,8 % (-6,2 % based on a screening test), and extremely high cardiovascular risk to a 0,0 % (-3,1 % based on a screening test). When studying men, the measurements have reduced to a 26,6 % and 10,9 % (-15,6 % and -4,7 % based on a screening test). Conclusion: Patients, studied in the family medicine clinic, have essentially improved risk factors due to quality treatment, that is enabled by the model of reference family medicine clinic, and graduate nurse's essential role in this model.