This paper presents the assessment of short-term wireless body area network (WBAN) exposure, which is operated at the industrial, scientific, and medical (ISM) band (2.45 GHz) in the vicinity of the human body. The experiment utilizes two popular textile antenna topologies, a planar monopole and a patch antenna as the radiating sources. The objective of this experiment is to investigate whether the exposure from WBAN may influence the physiological parameters (body temperature, blood pressure, and heart rate) and the well-being of the wearer. Counter-balanced, crossover, and the single-blind method was applied in the experimental setup. P-value is the probability value, under the assumption of no effect or no difference (the null hypothesis) of obtaining a result equal to or more extreme than what was actually observed. If P <0.05, it indicates that P-value will be less than the level of significance. Thus, the null hypothesis (no effect or no difference) can be rejected, and it can be concluded that there exist effects to the respondents. The results showed that there is statistically no significant difference between the active exposure and the Sham (no exposure) which may affect the physiological parameters and well-being of the wearers, with P >0.05, which failed to reject the null hypothesis (no effect).