Much of the literature on research design has focussed on research conducted in developed, uni-cultural or primarily English speaking countries. Studies of qualitative case study research, the challenges and prospects, have been embedded in Western/Euro-centric society and social theories. Although there have been some theoretical studies, few empirical studies have been conducted to explore the nature of the challenges of qualitative case study in Africa and Asia. These challenges include cultural and language issues affecting access to companies and respondent issues and data analysis and financial issues. The authors while conducting qualitative case study research in Libya and Malaysia faced these issues. The discussion in this paper examines these three issues in order to make a contribution toward the literature in this area.