The mechanism of quinolinic acid-induced neurite lesions: The role of NR2B, ROS and autophagy

Increased quinolinic acid (QA) has been suggested in various mental disease pathology. Excessive QA is shown to overactivate N-Methyl-D-aspartic acid (NMDA) receptor subunit 2B (NR2B) receptors and is deleterious to the neurons; however, the exact mechanism behind this effect is complex and not fully understood. This thesis aimed to investigate the mechanism of QA-induced neurite impairment.