The first extensive study of silver-doped lanthanum manganite nanoparticles for inducing selective cell death and enhancing radiation dose

The use of nanoparticles (NPs) for radiation dose enhancement is an ever-growing field that is founded upon the idea that high-Z nanoparticles will enhance radiation dose to cancer tissue. Introducing a novel approach to this concept with silver- doped Lanthanum Manganite (LAGMO) at silver doping's of 0, 2.5, 5 & 10% is both daunting and promising due to previous success witnessed with other NP's such as gold. The combination of nanoparticles and radiation necessitates a full characterisation of interaction, response and toxicity to both healthy and cancer cell lines. An understanding of these factors was achieved through monitoring the cell condition and growth of 9L Gliosarcoma (9LGS) brain cancer cells in comparison to Madin-Darby Canine Kidney (MDCK) cells.