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Investigations of peroxidation of membrane phospholipids

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posted on 2024-11-11, 19:37 authored by Colin H Cortie
The deterioration of lipids by oxygen, termed peroxidation, is a constitutive process in living systems. Enzymatic peroxidation is required for some forms of cell signalling, but the non-enzymatic peroxidation of polyunsaturated fatty acids (PUFA) produces numerous toxic and mutagenic products associated with pathology and aging. Phospholipids containing PUFA are common in mammalian membranes, but an inverse relationship has been found between membrane susceptibility to peroxidation and maximal lifespan (MLS). Past studies of peroxidation have focused on the PUFA content of phospholipids, but other elements of phospholipid composition including class and saturated fatty acid (SFA) or monounsaturated fatty acid (MUFA) content may also influence peroxidation. This thesis presents three studies investigating the relationship between phospholipid composition and peroxidation.

History

Year

2015

Thesis type

  • Not specified

Faculty/School

Illawarra Health and Medical Research Institute

Language

English

Disclaimer

Unless otherwise indicated, the views expressed in this thesis are those of the author and do not necessarily represent the views of the University of Wollongong.

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