Extracellular Chaperones and their Cell Surface Receptors

Nearly all biological systems require proteins to achieve and maintain their native, threedimensional conformation, however, various stresses and genetic mutations can cause proteins to misfold and aggregate. Both intracellular and extracellular protein aggregates are associated with protein deposition diseases (PDDs), such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS). Although the processes involved in maintaining intracellular protein quality control are well established, much less is known regarding the maintenance of extracellular proteostasis...