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Wastewater Microbiome Analysis for Population Alcohol Abuse

journal contribution
posted on 2024-11-17, 14:55 authored by Jiangping Wu, Yan Chen, Jiawei Zhao, Tanjila Alam Prosun, Jake William O’Brien, Lachlan Coin, Faisal I Hai, Martina Sanderson-Smith, Guangming Jiang
This study aims to unveil correlations between wastewater microbiota and the catchment-specific population health risk, specifically alcohol abuse, with smoking and obesity as confounding factors. Our study highlights the importance of extracting human-associated microbial communities from wastewater metagenomes by excluding environmental microorganisms, due to their irrelevance to human health. After excluding environmental microbes, we observed strong associations of all three health risk factors, including alcohol abuse, smoking and obesity, with the human gut microbiome in wastewater. The linear discriminant analysis effect size (LEfSe) analysis showed Lactococcus_A, Leuconostoc, Aeromicrobium, Akkermansia, Weissella, Limosilactobacillus, Klebsiella_A, Desulfovibrio and Cloacibacillus as potential microbial biomarkers for alcoholism, after accounting for the confounding effects of smoking and obesity. Functional annotations of microorganisms linked with lower alcoholism rates are primarily related to energy metabolism and intercellular communication. Microorganisms associated with higher alcoholism rates are predominantly involved in immune regulation and cellular DNA architecture. This study highlights the need for a comprehensive exploration of different health risk factors together to identify potential associations between the wastewater microbiome and population lifestyle.

Funding

University of Wollongong (DP190100385)

History

Journal title

Water (Switzerland)

Volume

16

Issue

15

Language

English

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