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Topographic plasticity in primary visual cortex is mediated by local corticocortical connections

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posted on 2024-11-14, 01:00 authored by Mike Calford, Layne L Wright, Andrew B Metha, Vivian Taglianetti
The placement of monocular laser lesions in the adult cat retina produces a lesion projection zone (LPZ) in primary visual cortex (V1) in which the majority of neurons have a normally located receptive field (RF) for stimulation of the intact eye and an ectopically located RF ( displaced to intact retina at the edge of the lesion) for stimulation of the lesioned eye. Animals that had such lesions for 14 - 85 d were studied under halothane and nitrous oxide anesthesia with conventional neurophysiological recording techniques and stimulation of moving light bars. Previous work suggested that a candidate source of input, which could account for the development of the ectopic RFs, was long-range horizontal connections within V1. The critical contribution of such input was examined by placing a pipette containing the neurotoxin kainic acid at a site in the normal V1 visual representation that overlapped with the ectopic RF recorded at a site within the LPZ. Continuation of well defined responses to stimulation of the intact eye served as a control against direct effects of the kainic acid at the LPZ recording site. In six of seven cases examined, kainic acid deactivation of neurons at the injection site blocked responsiveness to lesioned-eye stimulation at the ectopic RF for the LPZ recording site. We therefore conclude that long-range horizontal projections contribute to the dominant input underlying the capacity for retinal lesion-induced plasticity in V1.

History

Citation

Calford, M. B., Wright, L. L., Metha, A. B. & Taglianetti, V. (2003). Topographic plasticity in primary visual cortex is mediated by local corticocortical connections. The Journal of Neuroscience, 23 (16), 6434-6442.

Journal title

The Journal of Neuroscience

Volume

23

Issue

16

Pagination

6434-6442

Language

English

RIS ID

80076

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