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Tissue distribution of lignans in rats in response to diet, dose-response, and competition with isoflavones

journal contribution
posted on 2024-11-14, 14:51 authored by Timothy Murray, Jinguo Kang, Lee Astheimer, William PriceWilliam Price
This paper investigates the occurrence and distribution of the lignan metabolites enterodiol (END) and enterolactone (ENL) and the isoflavone daidzein (DAID) in rat tissues using liquid chromatography - electrospray ionisation mass spectrometry (LC – ESI/MSn) following a variety of dietary regimes. Further, we examined the dose-response and distribution of END and ENL in liver, testes, prostate and lung, and investigated the effects of competition between lignans and isoflavones on metabolite distribution. In liver, testes, prostate & lung tissue, dose related increases in END concentration were observed. In the testes, the co-administration of 60 mg/kg SDG with 60 mg/kg isoflavones produced alterations in the resulting metabolite profile, causing increased END concentration and decreased DAID concentration. Results indicate lignan accumulation in tissues occurs, and co-administration of lignans with isoflavones affects the metabolite profile, with effects dependent on tissue type.

History

Citation

T. Murray, J. Kang, L. Astheimer, and W.E. Price, Tissue distribution of lignans in rats in response to diet, dose-response, and competition with isoflavones. Journal of Agricultural and Food Chemistry, 2007. 55(12): p. 4907-4912

Journal title

Journal of Agricultural and Food Chemistry

Volume

55

Issue

12

Pagination

4907-4912

Language

English

RIS ID

22634

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