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The synthesis of 2',2'-bis-benzylisoquinolines and their cytostatic activities

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posted on 2024-11-14, 14:57 authored by Stephen R Taylor, Alison Ung, Stephen PyneStephen Pyne
The novel laudanosine dimers in which two laudanosine units are linked via a C-2′ biaryl bond have been prepared by a sequence that involves formation of the biaryl bond first and then formation of the isoquinoline rings. Two of these compounds showed higher cytostatic activity on three cancer cell lines than thalicarpine.

History

Citation

Taylor, S. R., Ung, A. T. & Pyne, S. G. (2007). The synthesis of 2'',2''-bis-benzylisoquinolines and their cytostatic activities. Tetrahedron, (63), 10896-10901.

Journal title

Tetrahedron

Volume

63

Issue

45

Pagination

10896-10901

Language

English

RIS ID

21133

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