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The Synthesis and Testing of Arenearylpyrimidylmethanes (AAPM) as Anti-Malarial Agents

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posted on 2024-11-14, 16:18 authored by N R Yepuri, R Haritakul, R Griffith, S P Leach, Paul KellerPaul Keller
The anti-malarial activity of the arenearylpyrimidylmethane (AAPM) class of compounds emerged from database searching of a pharmacophore. A new 2 step synthesis of the AAPM scaffold is reported and subsequent substitution yielded a short synthesis of the lead anti-malarial compound. The presence of atropisomerism in this class of compounds is also reported for the first time.

History

Citation

This article was originally published as: Yepuri, NR, Haritakul, R, Griffith, R, Leach, SP & Keller, PA, The Synthesis and Testing of Arenearylpyrimidylmethanes (AAPM) as Anti-Malarial Agents, ChemMedchem, 2006, 1(7), 715-717. Copyright 2005 John Wiley & Sons. Journal information available here.

Journal title

ChemMedChem

Volume

1

Issue

7

Pagination

715-717

Publisher website/DOI

Language

English

RIS ID

16736

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    Keywords

    anti-malarial activitydatabase searchingpharmacophoresynthesis designatropisomerismCMMB

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    Copyright - All rights reserved

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