Sound assessment of a role for fish oil in therapeutics or prevention of cardiovascular disease jeopardised by confused study design

The study by Galan and colleagues in the SU.FOL.OM3 collaborative group has added further confusion to the omega-3 story, which in this case largely derives from confusion in the study design. Confusion about the likely mechanism of cardiovascular protection and hence expected outcomes; confusion in the subject selection; confusion about the timing of intervention; confusion about the active components of fish oil.