Serotonin 2A receptor and its association with the pathology of schizophrenia

Dear Editor: Accumulated evidence suggests that serotonin 2A (5-HT2A) receptors are implicated in the pathology of schizophrenia. However the results remain inconclusive, particularly in the case of binding studies using postmortemtissue.We agreewith Dean's comment that our recent paper (Kang et al., 2009) reported a decrease in the density of [3H] ketanserin binding to the 5-HT2A receptors in the superior temporal gyrus (STG), which supported earlier findings in the planum temporal cortex (Pralong et al., 2000), despite Burnet et al. reporting previously that there was no change in [3H] ketanserin binding in the STG in schizophrenia (Burnet et al., 1996).............