Is Seladin-1 really a selective Alzheimer's disease indicator?
journal contribution
posted on 2024-11-16, 07:41 authored by Laura J Sharpe, Jenny Wong, Brett Garner, Glenda M Halliday, Andrew J BrownSelective Alzheimer's Disease Indicator-1 (Seladin-1) was originally identified by its down-regulation in the brains of Alzheimer's disease (AD) patients. Here, we re-examine existing data and present new gene expression data that refutes its role as a selective AD indicator. Furthermore, we caution against the use of the name “Seladin-1” and instead recommend adoption of the approved nomenclature, 3β-hydroxysterol Δ24-reductase (or DHCR24), which describes its catalytic function in cholesterol synthesis. Further work is required to determine what link, if any, exists between DHCR24 and AD.
Funding
EVIDENCE OF (SELF)TRAINING OF WORKERS IN THE PRESS: AFFECTING THE SENSES, PRODUCING SENSITIVITIES (between the final decades of the 19th century and the beginning of the 21st century)
Coordenação de Aperfeicoamento de Pessoal de Nível Superior
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