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Galvanic coupling conducting polymers to biodegradable Mg initiates autonomously powered drug release

journal contribution
posted on 2024-11-16, 06:21 authored by Simon Moulton, Mark Imisides, Gordon WallaceGordon Wallace, Roderick Shepherd
Electrical stimulation to affect localised and controlled release of therapeutic drugs is becoming an attractive option in the treatment of acute diseases or chronic illnesses. Currently the materials developed for this technique rely on power sources to operate, making their progression from the laboratory to the biomedical marketplace problematic. To help alleviate this issue, we have demonstrated autonomously powered controlled release of a drug by exploiting the galvanic couple between biodegradable Mg alloy and a conducting organicpolymer. We also demonstrate the ability to control the rate of drug release by utilizing a range of biodegradable polymer coatings on the Mg alloy. Combination of the biodegradable Mg and conducting polymer provides a biocompatible platform for the autonomously controlled release of a drug at therapeutic levels.

Funding

Nanobionics

Australian Research Council

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History

Citation

Moulton, S. E., Imisides, M. D., Shepherd, R. L. & Wallace, G. G. (2008). Galvanic coupling conducting polymers to biodegradable Mg initiates autonomously powered drug release. Journal of Materials Chemistry, 18 3608-3613.

Journal title

Journal of Materials Chemistry

Volume

18

Issue

30

Pagination

3608-3613

Language

English

RIS ID

27125

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