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Electrophysiological correlates of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism

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posted on 2024-11-15, 17:38 authored by Nikita Roy, Robert BarryRobert Barry, Francesca Fernandez, Chai Lim, Mahmoud Al-Dabbas, Diana Karamacoska, Samantha Broyd, Nadia SolowijNadia Solowij, Christine Chiu, Genevieve Steiner-LimGenevieve Steiner-Lim
2020, The Author(s). The brain-derived neurotrophic factor (BDNF) protein is essential for neuronal development. Val66Met (rs6265) is a functional polymorphism at codon 66 of the BDNF gene that affects neuroplasticity and has been associated with cognition, brain structure and function. The aim of this study was to clarify the relationship between BDNF Val66Met polymorphism and neuronal oscillatory activity, using the electroencephalogram (EEG), in a normative cohort. Neurotypical (N = 92) young adults were genotyped for the BDNF Val66Met polymorphism and had eyes open resting-state EEG recorded for four minutes. Focal increases in right fronto-parietal delta, and decreases in alpha-1 and right hemispheric alpha-2 amplitudes were observed for the Met/Met genotype group compared to Val/Val and Val/Met groups. Stronger frontal topographies were demonstrated for beta-1 and beta-2 in the Val/Met group versus the Val/Val group. Findings highlight BDNF Val66Met genotypic differences in EEG spectral amplitudes, with increased cortical excitability implications for Met allele carriers.

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Citation

Roy, N., Barry, R. J., Fernandez, F. E., Lim, C. K., Al-Dabbas, M. A., Karamacoska, D., Broyd, S. J., Solowij, N., Chiu, C. L. & Steiner, G. Z. (2020). Electrophysiological correlates of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism. Scientific Reports, 10 (1), 1-11.

Journal title

Scientific Reports

Volume

10

Issue

1

Language

English

RIS ID

146080

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