Dual Gold-Catalyzed Cycloaromatization of Unconjugated (E)-Enediynes

A synthesis of novel unconjugated (E)‐enediynes from allenyl amino alcohols is reported and their gold‐catalyzed cascade cycloaromatization to a broad range of enantioenriched substituted isoindolinones developed. Experimental and computational studies support the reaction proceeding via a dual‐gold σ,π‐activation mode involving a key gold‐vinylidene and allenyl‐gold containing intermediate.