University of Wollongong
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DoseMRT: A Software Package for Individualised Monte Carlo Dose Calculations of Synchrotron-Generated Microbeam Radiation Therapy

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This work describes the creation and experimental validation of DoseMRT, a new software package, and its associated workflow for dose calculations in synchrotron-generated broad beam and microbeam radiation treatment fields. The DoseMRT software package allows users to import CT DICOM datasets into Geant4 for Monte Carlo dose calculations. It also provides basic treatment planning capabilities, simplifying the complexity of performing Geant4 simulations and making our Monte Carlo dose calculation algorithm accessible to a broader range of users. To demonstrate the new package, dose calculations are validated against experimental measurements performed in homogeneous water tank phantoms and the anatomically complex Alderson Radiotherapy Phantom for both broad-beam and microbeam configurations. Additionally, DoseMRT is successfully utilised as the primary method for patient-specific treatment prescription in an in vivo experiment involving tumour-bearing rats at the Imaging and Medical Beamline of the Australian Synchrotron.

Funding

X-RATE: A novel radiation detector platform to realise new opportunities in radiotherapy at the Australian Synchrotron : National Health and Medical Research Council (NHMRC) | APP1093256

Design and application of new nanomaterials theranostic platforms for targeted treatment of cancer : National Health and Medical Research Council (NHMRC) | APP1084994

History

Journal title

Radiation

Volume

3

Issue

2

Pagination

123-137

Publisher

MDPI

Publication status

  • Published online

Language

en

Associated Identifiers

grant.6719678 (dimensions-grant-id); grant.7874485 (dimensions-grant-id)