Comparison of assays for measuring plasma paracetamol. Possibility of calibration error needs evaluation

Egleston et al report a significant difference in plasma paracetamol concen­ trations assayed with the AcetaSite bench assay and a standard laboratory assay. Rapid and accurate determinations of plasma paracetamol concentrations are crucial in the expeditious and appropriate administration of antidotal treatment, which prevents severe liver damage if given sufficiently early in the course of poisoning.