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Comparative study of alternative Geant4 hadronic ion inelastic physics models for prediction of positron-emitting radionuclide production in carbon and oxygen ion therapy

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posted on 2024-11-15, 15:55 authored by Andrew ChaconAndrew Chacon, Susanna GuatelliSusanna Guatelli, Harley Rutherford, David BolstDavid Bolst, Akram Mohammadi, Abdella Ahmed, Munetaka Nitta, Fumihiko Nishikido, Yuma Iwao, Hideaki Tashima, Eiji Yoshida, Go Akamatsu, Sodai Takyu, Atsushi Kitagawa, Theresa Hofmann, Marco Pinto, Daniel Franklin, Katia Parodi, Taiga Yamaya, Anatoly RozenfeldAnatoly Rozenfeld, Mitra Safavi-Naeini
The distribution of fragmentation products predicted by Monte Carlo simulations of heavy ion therapy depend on the hadronic physics model chosen in the simulation. This work aims to evaluate three alternative hadronic inelastic fragmentation physics options available in the Geant4 Monte Carlo radiation physics simulation framework to determine which model most accurately predicts the production of positron-emitting fragmentation products observable using in-beam PET imaging. Fragment distributions obtained with the BIC, QMD, and INCL + + physics models in Geant4 version 10.2.p03 are compared to experimental data obtained at the HIMAC heavy-ion treatment facility at NIRS in Chiba, Japan. For both simulations and experiments, monoenergetic beams are applied to three different block phantoms composed of gelatin, poly(methyl methacrylate) and polyethylene. The yields of the positron-emitting nuclei 11C, 10C and 15O obtained from simulations conducted with each model are compared to the experimental yields estimated by fitting a multi-exponential radioactive decay model to dynamic PET images using the normalised mean square error metric in the entrance, build up/Bragg peak and tail regions. Significant differences in positron-emitting fragment yield are observed among the three physics models with the best overall fit to experimental 12C and 16O beam measurements obtained with the BIC physics model.

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Citation

Chacon, A., Guatelli, S., Rutherford, H., Bolst, D., Mohammadi, A., Ahmed, A., Nitta, M., Nishikido, F., Iwao, Y., Tashima, H., Yoshida, E., Akamatsu, G., Takyu, S., Kitagawa, A., Hofmann, T., Pinto, M., Franklin, D. R., Parodi, K., Yamaya, T., Rosenfeld, A. & Safavi-Naeini, M. (2019). Comparative study of alternative Geant4 hadronic ion inelastic physics models for prediction of positron-emitting radionuclide production in carbon and oxygen ion therapy. Physics in Medicine and Biology, 64 (15), 155014-1-155014-16.

Journal title

Physics in Medicine and Biology

Volume

64

Issue

15

Language

English

RIS ID

138464

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