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Ceramide accumulation in L6 skeletal muscle cells due to increased activity of ceramide synthase isoforms has opposing effects on insulin action to those caused by palmitate treatment

journal contribution
posted on 2024-11-14, 22:20 authored by Georgia Frangioudakis, Barbara Diakanastasis, Bing-Qing M Liao, Jennifer Saville, Nolan J Hoffman, Todd MitchellTodd Mitchell, Carsten Schmitz-Peiffer
AIMS/HYPOTHESIS: An accumulation of ceramides has been implicated in the generation of insulin resistance in skeletal muscle upon an oversupply of fatty acid. Different ceramide species are generated through the actions of ceramide synthases (CerSs), which incorporate specific acyl side chains. We tested whether particular CerS isoforms promoted insulin resistance through the generation of more inhibitory ceramide species, thus representing potential targets for intervention.

History

Citation

Frangioudakis, G., Diakanastasis, B., Liao, B. M., Saville, J. T., Hoffman, N. J., Mitchell, T. W. and Schmitz-Peiffer, C. (2013). Ceramide accumulation in L6 skeletal muscle cells due to increased activity of ceramide synthase isoforms has opposing effects on insulin action to those caused by palmitate treatment. Diabetologia, 56 (12), 2697-2701.

Journal title

Diabetologia

Volume

56

Issue

12

Pagination

2697-2701

Publisher website/DOI

Language

English

RIS ID

81858

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    Keywords

    insulinactionthosecausedceramidepalmitateaccumulationtreatmentl6skeletalmusclecellsdueincreasedactivitysynthaseisoformshasopposingeffectsCMMB

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    Copyright - All rights reserved

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