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Antimalarial and cytotoxic activities of pregnene-type steroidal alkaloids from Holarrhena pubescens roots

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posted on 2024-11-14, 23:35 authored by Sarot Cheenpracha, Pannakorn Boapun, Thunwadee Limtharakul, Surat Laphookhieo, Stephen PyneStephen Pyne
The phytochemical investigation of an alkaloidal extract of Holarrhena pubescens roots led to the isolation and identification of a new pregnene-type alkaloid, mokluangin D (1), together with nine known steroidal alkaloids (2-10). The structure of the new metabolite was determined on the basis of spectroscopic analyses including 1D- and 2D-NMR spectroscopy and mass spectrometry. Compounds 3 and 4 showed potent antimalarial activity against Plasmodium falciparum K1 stain with IC50 values of 1.2 and 2.0 μM, respectively, and showed weak cytotoxic activity against the NCI-H187 cell line with IC50 values of 27.7 and 30.6 μM, respectively. The substituent groups at C-3 and the carbonyl group at C-18 are important for the activity against the P. falciparum K1 stain.

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Citation

Cheenpracha, S., Boapun, P., Limtharakul, T., Laphookhieo, S. & Pyne, S. G. (2019). Antimalarial and cytotoxic activities of pregnene-type steroidal alkaloids from Holarrhena pubescens roots. Natural Product Research, 33 (6), 782-788.

Journal title

Natural Product Research

Volume

33

Issue

6

Pagination

782-788

Language

English

RIS ID

117692

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