University of Wollongong
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A Novel Anthropomorphic Phantom Composed of Tissue-Equivalent Materials for Use in Experimental Radiotherapy: Design, Dosimetry and Biological Pilot Study

journal contribution
posted on 2024-11-17, 15:37 authored by Thomas Breslin, Jason Paino, Marie Wegner, Elette Engels, Stefan Fiedler, Helen Forrester, Hannes Rennau, John Bustillo, Matthew Cameron, Daniel Häusermann, Christopher Hall, Dieter Krause, Guido Hildebrandt, Michael Lerch, Elisabeth Schültke
The production of anthropomorphic phantoms generated from tissue-equivalent materials is challenging but offers an excellent copy of the typical environment encountered in typical patients. High-quality dosimetry measurements and the correlation of the measured dose with the biological effects elicited by it are a prerequisite in preparation of clinical trials with novel radiotherapy approaches. We designed and produced a partial upper arm phantom from tissue-equivalent materials for use in experimental high-dose-rate radiotherapy. The phantom was compared to original patient data using density values and Hounsfield units obtained from CT scans. Dose simulations were conducted for broad-beam irradiation and microbeam radiotherapy (MRT) and compared to values measured in a synchrotron radiation experiment. Finally, we validated the phantom in a pilot experiment with human primary melanoma cells.

Funding

Deutscher Akademischer Austauschdienst (19173)

History

Journal title

Biomimetics

Volume

8

Issue

2

Language

English

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