Andreas Kurtz, Charite Universitatsmedizin
Stefanie Seltmann, Charite Universitatsmedizin
Amos Bairoch, Computer Analysis and Laboratory Investigation of Proteins of Human Origin group
Marie-Sophie Bittner, Charite Universitatsmedizin
K Bruce, Roslin Cells Ltd.
Amanda Capes-Davis, Children's Medical Research Institute
Laura Clarke, European Bioinformatics Institute
Jeremy Micah Crook, University of WollongongFollow
Laurence Daheron, Harvard iPSC Core Facility
Johannes Dewender, Charite Universitatsmedizin
Adam Faulconbridge, European Bioinformatics Institute
Wataru Fujibuchi, Kyoto University
Alexander Gutteridge, Pfizer Global Research and Development
Derek Hei, University of Wisconsin
Yong-Ou Kim, National Institute of Health and Korea Centers for Diseases Control and Prevention
Jung-Hyun Kim, Korea National Institute of Health
Anja Kolb-Kokocinski, Wellcome Trust Sanger Institute
Fritz Lekschas, Charite Universitatsmedizin
Geoffrey Lomax, California Institute for Regenerative Medicine
Jeanne F. Loring, Scripps Research Institute
Tenneille Ludwig, WiCell Research Institute
Nancy Mah, Charite Universitatsmedizin
Tohru Matsui, Keio University
Robert Muller, Charite Universitatsmedizin
Helen Parkinson, European Bioinformatics Institute
Michael Sheldon, The State University of New Jersey
Kelly P. Smith, University of Massachusetts
Harald Stachelscheid, Berlin Institute of Health
Glyn N. Stacey, Medicines And Healthcare Products Regulatory AgencyFollow
Ian Streeter, European Bioinformatics Institute
Anna Veiga, Center of Regenerative Medicine in Barcelona
Ren-He Xu, University of Macau, University of Connecticut



Publication Details

Kurtz, A., Seltmann, S., Bairoch, A., Bittner, M., Bruce, K., Capes-Davis, A., Clarke, L., Crook, J. M., Daheron, L., Dewender, J., Faulconbridge, A., Fujibuchi, W., Gutteridge, A., Hei, D. J., Kim, Y., Kim, J., Kolb-Kokocinski, A., Lekschas, F., Lomax, G. P., Loring, J. F., Ludwig, T., Mah, N., Matsui, T., Muller, R., Parkinson, H., Sheldon, M., Smith, K., Stachelscheid, H., Stacey, G., Streeter, I., Veiga, A. & Xu, R. (2018). A Standard Nomenclature for Referencing and Authentication of Pluripotent Stem Cells. Stem Cell Reports, 10 (1), 1-6.


Unambiguous cell line authentication is essential to avoid loss of association between data and cells. The risk for loss of references increases with the rapidity that new human pluripotent stem cell (hPSC) lines are generated, exchanged, and implemented. Ideally, a single name should be used as a generally applied reference for each cell line to access and unify cell-related information across publications, cell banks, cell registries, and databases and to ensure scientific reproducibility. We discuss the needs and requirements for such a unique identifier and implement a standard nomenclature for hPSCs, which can be automatically generated and registered by the human pluripotent stem cell registry (hPSCreg). To avoid ambiguities in PSC-line referencing, we strongly urge publishers to demand registration and use of the standard name when publishing research based on hPSC lines. In this article Kurtz, Seltmann and colleagues propose a standard nomenclature and registry for human pluripotent stem cells. The nomenclature is based on fixed name elements and provides a unique identifier for PSC lines suitable for referencing over diverse data sources, registries, publications, and cell banks. Rigorous application is needed to reduce risks from misidentification and false referencing of lines and data.



Link to publisher version (DOI)