Gold-loaded nanoporous superparamagnetic nanocubes for catalytic signal amplification in detecting miRNA

Authors

Mostafa Kamal Masud, University of Wollongong, Griffith UniversityFollow
Md Nazmul Islam, Griffith University
Md Hakimul Haque, Griffith University
Shunsuke Tanaka, University of WollongongFollow
Vinod Gopalan, Griffith University
Gursel Alici, University of WollongongFollow
Nam-Trung Nguyen, Griffith UniversityFollow
Alfred K. Lam, Griffith University
Md. Shahriar Al Hossain, University of Wollongong, National Institute for Materials ScienceFollow
Yusuke Yamauchi, University of Wollongong, National Institute for Materials ScienceFollow
Muhammad J. A Shiddiky, Griffith University

RIS ID

115241

Publication Details

Masud, M. Kamal., Islam, M., Haque, M. Hakimul., Tanaka, S., Gopalan, V., Alici, G., Nguyen, N., Lam, A. K., Hossain, M. Al., Yamauchi, Y. & Shiddiky, M. J. A.(2017). Gold-loaded nanoporous superparamagnetic nanocubes for catalytic signal amplification in detecting miRNA. Chemical Communications, (58), 8231-8234.

Abstract

This paper reports the development of a nonenzymatic, amplificationfree, and sensitive platform for the detection of microRNA based on a new class of electrocatalytically active superparamagnetic gold-loaded nanoporous iron oxide nanocubes (Au@NPFe2O3NC). The assay showed an excellent detection sensitivity down to 100 fM and specificity towards the analysis of miR-21 in cell lines and tissue samples derived from patients with oesophageal squamous-cell carcinoma (ESCC).