Modelling disrupted-in-schizophrenia 1 loss of function in human neural progenitor cells: tools for molecular studies of human neurodevelopment and neuropsychiatric disorders
Human neural progenitor cells (NPCs) offer a new strategy for de novo modelling of neurodevelopment and neuropsychiatric disease.1 They can be derived from numerous stem cell types including embryonic and adult stem cells, or isolated from neurogenic tissues of the human central nervous system. As lineage-restricted cells, NPCs are self-renewing and easily differentiated to neurons, astrocytes and oligodendrocytes using methods that emulate in vivo development and neural cell replacement. Genetically modified cells can be generated to exhibit disease-related phenotypes and aberrant mechanisms for cellular and molecular analysis. Furthermore, they have the potential to be used as tools for early phase drug discovery by predicting in vivo drug response through in vitro cell-based assayology of drug candidates.