Year

2000

Degree Name

Master of Science (Hons.)

Department

Department of Biological Sciences

Abstract

Strong experimental and clinical evidence indicates that the urokinase type plasminogen activation system is associated with many types of human cancer invasion and metastasis. A component of this system, which is over-expressed on cancer cell surfaces, urokinase plasminogen activator (uPA) is a potential marker that may be targeted for anticancer therapy. The naturally occurring inhibitor, plasminogen activator inhibitor type 2 (PAI-2), binds specifically to activated cell surface bound uPA. Thus, the overall aim of this project was to assess the viability of using human recombinant PAI-2 as a potential targeting device in future anti-cancer therapy projects.

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