Year
1979
Degree Name
Master of Science
Department
Department of Chemistry
Recommended Citation
Wiecek, C., The determination of steric purity of amines and amino acids gas chromatography and mass spectrometry, Master of Science thesis, Department of Chemistry, University of Wollongong, 1979. https://ro.uow.edu.au/theses/2634
Abstract
Amines and amino acids have been condensed with a mixture of N-TFA-R-prolyl chloride and N-TFA-S-(1-^H)-prolyl chloride and the resulting four diastereoisomers have been separated by Gas Chromatography into two peaks. The amount of each diastereoisomer formed was then determined by Chemical Ionisation Mass Spectrometry. The steric purity of the enantiomeric mixtures was calcuated from these values and the calculated values were always found to be within 5% of the expected values.
Unless otherwise indicated, the views expressed in this thesis are those of the author and do not necessarily represent the views of the University of Wollongong.