Year
2000
Degree Name
Doctor of Philosophy
Department
Department of Chemistry
Recommended Citation
Luu, Tien T.T., Studies in reverse transcriptase: synthesis of inhibitors, conformational analysis, and integration of drug design, Doctor of Philosophy thesis, Department of Chemistry, University of Wollongong, 2000. https://ro.uow.edu.au/theses/1176
Abstract
The reverse transcriptase (RT) enzyme of the human immunodeficiency virus is an attractive target for rational drug design as it is an essential and unique enzyme in the viral life cycle. RT can be inhibited by non-nucleoside inhibitors acting at an allosteric binding pocket (NNIBP). The inherent flexibility of the enzyme has made the study of the mechanism(s) of its functions and inhibition by non-nucleoside inhibitors difficult and ambiguous. Furthermore, this flexibility in the NNIBP has made it difficult to characterise the binding pocket for rational drug design.
Unless otherwise indicated, the views expressed in this thesis are those of the author and do not necessarily represent the views of the University of Wollongong.