RIS ID

27141

Publication Details

Chikhani, S., Fernandez, F., Poetter, K., Toohey, B., Harvey, R. & Griffiths, L. (2008). Investigation between the S377G3 GATA-4 polymorphism and migraine. The Open Neurology Journal, 2 35-38.

Abstract

Migraine is a common and painful neurological disorder, with genetic and environmental components. Several conditions have been shown to be comorbid with migraine, notably a cardiac malformation affecting the interatrial septum and leading to patent foramen ovale (PFO). Mutations in the development regulatory gene GATA-4, located on human chromosome 8p23.1-p22, have been found to be responsible for some cases of congenital heart defects including PFO. To determine whether the GATA-4 gene is involved in migraine, the present study performed an association analysis of a common GATA-4 variant that results in a change of amino acid (S377G), in a large case/control population (275 unrelated Caucasian migraineurs versus 275 control individuals). The results showed that there was no significant association for this polymorphism between migraine and controls (x2 = 0.84, P = 0.66). Thus it appears that the GATA-4 (S377G) mutation does not play a significant role in common migraine susceptibility.

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Link to publisher version (DOI)

http://dx.doi.org/10.2174/1874205X00802010035