Genetic imaging consortium for addiction medicine: From neuroimaging to genes

Authors

Scott Mackey, University of Vermont
Kees-Jan Kan, University of Vermont
Bader Chaarani, University of Vermont
Nelly Alia-Klein, Icahn School of Medicine at Mount Sinai
Albert Batalla, University of Barcelona
Samantha Brooks, University of Cape Town
Janna Cousijn, University of Amsterdam
Alain Dagher, McGill University
Michiel De Ruiter, Netherlands Cancer Institute
Sylvane Desrivieres, Kings College London
Sarah W. Feldstein Ewing, Oregon Health & Sciences University
Rita Goldstein, Icahn School of Medicine at Mount Sinai
Anna Goudriaan, University of Amsterdam
Mary M. Heitzeg, University of Michigan
Kent Hutchison, University of Colorado
Chiang-Shan R. Li, Yale University
Edythe D. London, University of California
Valentina Lorenzetti, Monash University
Maartje Luijten, Radboud University Nijmegen
Rocio Martin-Santos, University of Barcelona
Angelica M. Morales, University of California
Martin P. Paulus, University of California
Tomas Paus, University of Toronto
Godfrey Pearlson, Yale University
Renee Schluter, University of Amsterdam
Reza Momenan, Institute on Alcohol Abuse and Alcoholism
Lianne Schmaal, VU University Medical Center
Gunter Schumann, Kings College London
Rajita Sinha, Yale University
Zsuzsika Sjoerds, University of Southern California
Dan J. Stein, University of Cape Town
Elliot A. Stein, National Institute on Drug Abuse
Nadia Solowij, University of WollongongFollow
Susan Tapert, Laureate Institute For Brain Research, Tulsa, Usa
Anne Uhlmann, University of Cape Town
Dick Veltman, Vu University Medical Centre
Ruth Van Holst, University of Amsterdam
Hendrik Walter, Charite Universitatsmedizin
Margaret J. Wright, Qimr Berghofer Medical Research Institute, Brisbane
Murat Yucel, University of Melbourne, Monash UniversityFollow
Murat Yucel, University of Melbourne, Monash University
Deborah Yurgelun-Todd, University of Utah School Of Medicine
Derrek P. Hibar, University of Southern California
Neda Jahanshad, University of Southern California
Paul M. Thompson, University of Southern California
David Glahn, Yale University
Hugh Garavan, University of Vermont
Patricia Conrod, Universite de Montreal

RIS ID

107113

Publication Details

Mackey, S., Kan, K., Chaarani, B., Alia-Klein, N., Batalla, A., Brooks, S., Cousijn, J., Dagher, A., De Ruiter, M., Desrivieres, S., Feldstein Ewing, S. W., Goldstein, R., Goudriaan, A., Heitzeg, M. M., Hutchison, K., Li, C. R., London, E. D., Lorenzetti, V., Luijten, M., Martin-Santos, R., Morales, A. M., Paulus, M. P., Paus, T., Pearlson, G., Schluter, R., Momenan, R., Schmaal, L., Schumann, G., Sinha, R., Sjoerds, Z., Stein, D. J., Stein, E. A., Solowij, N., Tapert, S., Uhlmann, A., Veltman, D., Van Holst, R., Walter, H., Wright, M. J., Yucel, M., Yucel, M., Yurgelun-Todd, D., Hibar, D. P., Jahanshad, N., Thompson, P. M., Glahn, D., Garavan, H., Conrod, P. et al (2016). Genetic imaging consortium for addiction medicine: From neuroimaging to genes. Progress in Brain Research, 224 203-223.

Abstract

Since the sample size of a typical neuroimaging study lacks sufficient statistical power to explore unknown genomic associations with brain phenotypes, several international genetic imaging consortia have been organized in recent years to pool data across sites. The challenges and achievements of these consortia are considered here with the goal of leveraging these resources to study addiction. The authors of this review have joined together to form an Addiction working group within the framework of the ENIGMA project, a meta-analytic approach to multisite genetic imaging data. Collectively, the Addiction working group possesses neuroimaging and genomic data obtained from over 10,000 subjects. The deadline for contributing data to the first round of analyses occurred at the beginning of May 2015. The studies performed on this data should significantly impact our understanding of the genetic and neurobiological basis of addiction.