Teasaponin improves central leptin sensitivity in high-fat diet-induced obese mice
Purpose: Leptin promotes negative energy balance by suppressing energy intake (EI) and elevating energy expenditure through its central action. Central leptin resistance is a hallmark of diet-induced obesity (DIO). Oral administration of teasaponin (TS) can reduce body weight and fat mass. However, little is known if TS has benefit effect in improving central leptin sensitivity. This study investigated the effects of TS on central leptin sensitivity and leptin signalling in the hypothalamic arcuate nucleus (Arc) of DIO mice. Methods: After 15 weeks of high-fat diet, DIO mice (n=40) were divided into two groups received either intraperitoneal (ip) injection of TS (10mg/kg, daily) or saline for 20 days. Another group of mice was fed low-fat diet (LF) as control (n=20). Then both DIO mice and LF mice were given intracerebroventricular (i.c.v.) injection of leptin or saline. Food intake and pSTAT3 level in the Arc in response to central leptin administration were assessed. Results: TS significantly decreased body weight gain (-210%, p
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