Asymmetric synthesis of indole homo-michael adducts via dynamic kinetic friedel-crafts alkylation with cyclopropanes

Authors

Steven M. Wales, University of North Carolina at Chapel HillFollow
Morgan M. Walker, University of North Carolina at Chapel Hill
Jeffrey S. Johnson, University of North Carolina at Chapel Hill

RIS ID

79736

Publication Details

Wales, S. M., Walker, M. M. & Johnson, J. S. (2013). Asymmetric synthesis of indole homo-michael adducts via dynamic kinetic friedel-crafts alkylation with cyclopropanes. Organic Letters, 15 (10), 2558-2561.

Abstract

An enantioconvergent Friedel–Crafts alkylation of indoles with donor–acceptor cyclopropanes is described. The reaction is catalyzed by pybox•MgI2 and proceeds via a type I dynamic kinetic asymmetric transformation (DyKAT).