Title

Asymmetric synthesis of indole homo-michael adducts via dynamic kinetic friedel-crafts alkylation with cyclopropanes

RIS ID

79736

Publication Details

Wales, S. M., Walker, M. M. & Johnson, J. S. (2013). Asymmetric synthesis of indole homo-michael adducts via dynamic kinetic friedel-crafts alkylation with cyclopropanes. Organic Letters, 15 (10), 2558-2561.

Abstract

An enantioconvergent Friedel–Crafts alkylation of indoles with donor–acceptor cyclopropanes is described. The reaction is catalyzed by pybox•MgI2 and proceeds via a type I dynamic kinetic asymmetric transformation (DyKAT).

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Link to publisher version (DOI)

http://dx.doi.org/10.1021/ol4010646