Title

Highly enantioselective reaction of 2-oxindoles with (3-indolyl)methanols by cooperative Catalysis of a Lewis acid and organocatalyst

RIS ID

108719

Publication Details

Ren, C., Zhang, T., Wang, X., Wu, T., Ma, J., Xuan, Q., Wei, F., Huang, H., Wang, D. & Liu, L. (2014). Highly enantioselective reaction of 2-oxindoles with (3-indolyl)methanols by cooperative Catalysis of a Lewis acid and organocatalyst. Organic and Biomolecular Chemistry, 12 (48), 9881-9886.

Abstract

An efficient cooperative biscinchona alkaloid and Lewis acid catalytic system was developed in the enantioselective α-alkylation of 2-oxindoles with (3-indolyl)(phenyl)methanols to provide (2-oxindole)-linker-indole derivatives in good yields (70-83%) with high enantioselectivities (81%-92%).

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Link to publisher version (DOI)

http://dx.doi.org/10.1039/c4ob02035a