RIS ID
58084
Abstract
Selective Alzheimer's Disease Indicator-1 (Seladin-1) was originally identified by its down-regulation in the brains of Alzheimer's disease (AD) patients. Here, we re-examine existing data and present new gene expression data that refutes its role as a selective AD indicator. Furthermore, we caution against the use of the name “Seladin-1” and instead recommend adoption of the approved nomenclature, 3β-hydroxysterol Δ24-reductase (or DHCR24), which describes its catalytic function in cholesterol synthesis. Further work is required to determine what link, if any, exists between DHCR24 and AD.
Grant Number
NHMRC/568884
Publication Details
Sharpe, L. J., Wong, J., Garner, B., Halliday, G. M. & Brown, A. J. (2012). Is Seladin-1 really a selective Alzheimer's disease indicator?. Journal of Alzheimer's Disease, 30 (1), 35-39.