Efficient synthesis and antioxidant activity of coelenterazine analogues

Authors

Yueting Lu, University of WollongongFollow
Rudi Hendra, University of WollongongFollow
Aaron J. Oakley, aarono@uow.edu.auFollow
Paul A. Keller, University of WollongongFollow

RIS ID

95383

Publication Details

Lu, Y., Hendra, R., Oakley, A. J. & Keller, P. A. (2014). Efficient synthesis and antioxidant activity of coelenterazine analogues. Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry, 55 (45), 6212-6215.

Abstract

A convenient and highly convergent method for the synthesis of new imidazo[1,2-a]pyridine-based coelenterazine analogues is reported. The imidazo[1,2-a]pyridine core was constructed through a condensation between 2-aminopyridine analogues and arylglyoxals. Additionally, a new approach to the synthesis of benzylglyoxals was introduced. The imidazo[1,2-a]pyridines display moderate antioxidant activities at a low micromolar level in 2,2-diphenyl-1-picrylhydrazyl (DPPH).