Title

Efficient synthesis and antioxidant activity of coelenterazine analogues

RIS ID

95383

Publication Details

Lu, Y., Hendra, R., Oakley, A. J. & Keller, P. A. (2014). Efficient synthesis and antioxidant activity of coelenterazine analogues. Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry, 55 (45), 6212-6215.

Abstract

A convenient and highly convergent method for the synthesis of new imidazo[1,2-a]pyridine-based coelenterazine analogues is reported. The imidazo[1,2-a]pyridine core was constructed through a condensation between 2-aminopyridine analogues and arylglyoxals. Additionally, a new approach to the synthesis of benzylglyoxals was introduced. The imidazo[1,2-a]pyridines display moderate antioxidant activities at a low micromolar level in 2,2-diphenyl-1-picrylhydrazyl (DPPH).

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Link to publisher version (DOI)

http://dx.doi.org/10.1016/j.tetlet.2014.09.065