Title

Chemoselective reduction of 2-acyl-N-sulfonylpyrroles: synthesis of 3-pyrrolines and 2-alkylpyrroles

RIS ID

95174

Publication Details

You, H., Grosse, A. C., Howard, J. K., Hyland, C. J. T., Just, J., Molesworth, P. P. & Smith, J. A. (2011). Chemoselective reduction of 2-acyl-N-sulfonylpyrroles: synthesis of 3-pyrrolines and 2-alkylpyrroles. Organic and Biomolecular Chemistry, 9 (10), 3948-3953.

Abstract

The partial reduction of pyrroles is not a common practice even though it offers a potential route to pyrroline building blocks, commonly used for synthesis. We have investigated the reduction of 2-acyl-N-sulfonylpyrroles and by varying the hydride source and solvent, achieved a chemoselective reduction, leading to 3-pyrrolines and alkyl pyrroles in high yield.

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Link to publisher version (DOI)

http://dx.doi.org/10.1039/c1ob05111c