Title

Cutting the forest to see a single tree?

RIS ID

94203

Publication Details

van Oijen, A. M. (2008). Cutting the forest to see a single tree?. Nature Chemical Biology, 4 (8), 440-443.

Abstract

The development of single-molecule tools has significantly impacted the way we think about biochemical processes. Watching a single protein in action allows us to observe kinetic details and rare subpopulations that are hidden in ensemble-averaging techniques. I will discuss here the pros and cons of the single-molecule approach in studying ligand binding in macromolecular systems and how these techniques can be applied to characterize the behavior of large multicomponent biochemical systems.

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Link to publisher version (DOI)

http://dx.doi.org/10.1038/nchembio0808-440