The reduced effect of serotonin on oxygen consumption during muscle contraction in the autoperfused rat hindlimb

Authors

Andrew Hoy, University of WollongongFollow
Gregory E. Peoples, University of WollongongFollow
Peter L. McLennan, University of WollongongFollow

RIS ID

74052

Publication Details

Hoy, A., Peoples, G. E. & McLennan, P. L. (2003). The reduced effect of serotonin on oxygen consumption during muscle contraction in the autoperfused rat hindlimb. Exercise, Muscle & Metabolism (pp. 1-1). Melbourne: Deakin University.

Abstract

Serotonin (5-HT) has been shown to reduce skeletal muscle oxygen consumption cY 02) during resting conditions in a variety of animal models. It is thought to act through redistribution of blood flow within skeletal muscle directing flow away from muscle tissue (nutritive bed) towards less metabolically active tissue, adipose and septum (non-nutritive bed) by selective vasoconstriction. The aim of this study was to test whether the effects of 5-HT (previously observed under resting conditions) are reproducible during the increased metabolic demand of muscle contraction.