Title

Rare presentation of Rosai-Dorfman disease mimicking a cervical intramedullary spinal cord tumor

RIS ID

88742

Publication Details

El Molla, M. EI., Mahasneh, T., Holmes, S. & Al-Khawaja, D. (2014). Rare presentation of Rosai-Dorfman disease mimicking a cervical intramedullary spinal cord tumor. World Neurosurgery, 81 (2), 442.E7-442.E9.

Abstract

Background Rosai-Dorfman disease, or sinus histiocytosis with massive lymphadenopathy, is a rare, benign, lymphoproliferative disorder that commonly manifests as a massive painless cervical lymphadenopathy with associated fever and weight loss. Central nervous system involvement is extremely rare, and cervical spinal cord manifestation has not been reported. Methods A 76-year-old man presented with a 10-week history of right hemiparesis. Magnetic resonance imaging identified an enhancing cervical intramedullary lesion consistent with a primary spinal cord tumor. Results Histopathology revealed intramedullary histiocytosis. Conclusions This cervical presentation of Rosai-Dorfman disease with central nervous system involvement suggests variation in the clinical manifestations of the disease, necessitating greater surgical awareness.

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Link to publisher version (DOI)

http://dx.doi.org/10.1016/j.wneu.2013.01.002